Program / Dept 1
Program / Dept 2
Short Research Description
The immune system has a remarkable ability to remember its previous encounters with a specific pathogen. Upon re-exposure to a pathogen, the immune system reacts at an accelerated rate and controls the invading pathogen expeditiously. The ability of the immune system to remember prior encounters is termed “immunological memory,” which is due to induction of memory T and B cells. Although induction of memory T and B cells memory is the basis of vaccination, the molecular mechanisms that govern the quantity, quality and duration of memory-dependent protective immunity are not well understood.
CD8 T cells play an important role in defense against viruses, bacteria and protozoa. Therefor, there is a need to develop vaccines that allow the CD8 T cells to maintain protective immunity against these pathogens. Protective immunity depends on the quality and quantity of memory CD8 T cells. Our research is focused on understanding the molecular mechanisms that govern the number and quality of memory CD8 cells.